| Pair Name | Bufalin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | ||
| Phytochemical Name | Bufalin (PubChem CID: 9547215 ) | ||
| Anticancer drug Name | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PubChem CID: 4713 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Bufalin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BIRC5 | hsa332 |
| Up-regulation | Expression | CASP3 | hsa836 | |
| In Vitro Model | NB4 | Acute promyelocytic leukemia | Homo sapiens (Human) | CVCL_0005 |
| Result | Bufalin is a potential regimen to be used in combination with conventional chemotherapeutic drugs to improve acute promyelocytic leukemia therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expressionBufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression. Acta Haematol. 2012;128(3):144-50. doi: 10.1159/000339424. | Click |
